Credits: 15. Grading scale: TH. Compulsory for: B3. Course coordinator: Olle Holst, olle.holst@biotek.lu.se, Gunnar Lidén, gunnar.liden@chemeng.lth.se, och Christian Trägårdh, christian.tragardh@livstek.lth.se, Livsmedelsteknik. Prerequisites: KKK070 Biotechnology, KAT090 Chemical Engineering- Transport Processes and KMB060 Microbiology. Recommended prerequisites: KAT031 Chemical Engineering- Separation Processes, KFK080 Thermodynamics, KBK011 Biochemistry, FMA410 Calculus in one variable, FMA420 Linear algebra and FMA430 Calculus in several variables. Assessment: Written and oral examinations, written reports and oral presentaions, hand-in assignments. Approved computer exercises. Written and oral report evaluations. The final grading will be based on the average of the different parts. Parts: 4.

Aim

• Achieve integrated skills and capabilities of technologies important for the food and biotechnical industry

• Achieve capability to solve problems which include choice of reactor, reactor computations in industrial processes

• Training in problems analysis/solving and critical evaluation.

• Apply and deepen skills from the courses in biotechnology, transport processes, separation processes, thermodynamics, microbiology and mathematics in industrial applications.

Contents
Throughout the course there are lectures, group exercises and study visits.

The course comprises four parts:

Reaction engineering (5p)

• Reactor models (the completely back-mixed stirred tank reactor, the plug flow reactor)

• Batch reactors

• Non-ideal reactors

• Energy balances for reacting systems

• Mass transfer and reactions

• Heterogenous systems, in particular gas-liquid systems

• Reactor simulations using ODEs.

• Industrial microorganisms. Fermentation technology incl. raw materials and substrates, microbial kinetics, bioreactors, sterilization of liquids, gases and equipments, measurement and control. Survey of separation processes.

• Sterilisation/pasteurisation is a non-isothermal reactor where simultaneously desired as well as non-desired chemical and micobial reactions take place. Also other means of sterilisation such as electromagnetic waves, high pressure and high electric fields will be introduced.

• Drying – a mass and heat transport driven process as here for hygroscopic products often implying chemical reactions and involves phase transition (evaporation of the solvent).

• Freezing - a mass and heat transport driven process often implying chemical reactions and involves phase transition (crystallisation of the solvent).

• Membranfiltration – a separation technology based on molecular "sieving"; an extension to the course in separation processes.

• Mixing– flow phenomena aimed at creating homogenesous products for miscible as well as non-miscble liquids.

• Cleaning processes- fundamental principles for "cleaning-in-place" (CIP) and "cleaning-out of-place" (COP) founded on governing transport phenomena and chemical reactions.

Literature
Danielsson, N. Å.: Kemisk reaktionsteknik
Sandkvist, Carin, Att skriva tekniska och vetenskapliga rapporter, anvisningar för Kemiteknikprogrammet och Bioteknikprogrammet, 2001.
Doran, Pauline M. Bioprocess Engineering Principles, Academic Press 1997.
Kessler, Heinz-Gerhard, Food and Bio Process Engineering, Dairy Technology, Verlag A. Kessler, 2002
Van Loan C. F. Introduction to Scientific Computing: A Matrix Vector Approach using Matlab, Prentice Hall, 2000
alternativt
Nakamura, Shoichiro, Numerical Analysis and Graphic Visualization with Matlab, Second Edition, Prentice Hall, 2002
Kessler, Heinz-Gerhard, Food and Bio Process Engineering, Dairy Technology, Verlag A. Kessler, 2002

Code: 0103. Name: Reaction Engineering.
Credits: 5. Grading scale: TH. Assessment: Written examination and computer assignments. Contents: The course will provide problem solving skills concerning reactor calculations for industrial processes. Furthermore, the course will provide an understanding of the interplay between reaction and mass transfer in chemical and biotechnical processes. Further information: Organisation: Partly given withe the course Chemical Reaction Engineering. It comprises lectures, exercises and computational assignments..

Code: 0203. Name: Microbial process technology.
Credits: 3. Grading scale: TH. Assessment: Written examination. Contents: Industrial microorganisms. Fermentation technology incl. raw materials and substrates, microbial kinetics, bioreactors, sterilization of liquids, gases and equipments, measurement and control. Survey of separation processes. .

Code: 0303. Name: Unit operations for the food and biotechnical industry.
Credits: 3. Grading scale: TH. Assessment: Written examination and computer assignments. Contents: Achieve knowledge and understanding of unit operations important for industrial production. Descriptions of their use, common equipment and computations to predict their performance. The complex physical properties of biological products and thermal unstable properties will be considered in the theoretical as well as the applied parts of the course. Further information: Organisation: Redovisningarna i projektlaborationsdelkursen (BLT010 0403) utformas och utgör en del av föreläsningarna i denna delkurs.

Code: 0403. Name: Project laboratory-work in unit operations and microbial process technology.
Credits: 4. Grading scale: TH. Assessment: Written reports and oral presentations. Written evaluations of the reports. Compulsory presence at all presentations and reporting meetings. Opposition at presentations. Contents: In this part a process technology case will be studied in the format of a project. It will give training in operating a project and in group work. The project work includes literature study, experimental planning, laboratory work to obtain data required to solve the issues of the case.