Course syllabus

Läkemedelskemi
Medicinal Chemistry

KOKN01, 7,5 credits, A (Second Cycle)

Valid for: 2018/19
Decided by: PLED B/K
Date of Decision: 2018-03-21

General Information

Compulsory for: B4-l, K4-l
Elective for: N4-nbm
Language of instruction: The course will be given in English on demand

Aim

The aim of the course is to give basic knowledge in and broad understanding of medicinal chemistry and pharmacological principles from a molecular perspective.

Learning outcomes

Knowledge and understanding
For a passing grade the student must

• be able to describe the most common strategies for drug discovery and development
• be able to describe common target molecules for drug development
• be able to describe basic pharmacodynamic and pharmacokinetic concepts from a molecular perspective
• be able to explain relationships between chemical structure and biological activity
• be able to describe chemical principles for design and development of drug molecules
• be able to name some of the most common drug compounds and their areas of use

Competences and skills
For a passing grade the student must

• be able to discuss chemical, physical, and pharmacokineticproperties of given drug molecules
• be able to describe and discuss drug action mechanisms from a molecular perspetive based on conformational analysis, steroechemistry, acid-base chemstry and ligand-macromolecule interactions
• be able to analyse the potenital of a given molecule structure as a drug candidate

Judgement and approach
For a passing grade the student must

• be able to analyse and judge a given molecular structure as potential drug candidat
• be able to analyse his/hers views and arguments for the judgement of a molecular structure as a potential drug candidate

Contents

The course discusses general pharmacological principles, drug development and presents various classes of drugs, their effects, their use, and chemical structures. Important parts of medicinal chemistry, such as drugs of the nerve system, hormone drugs, drugs affecting the heart, respiratory drugs, anaesthetics, sedative drugs, antivirals, antibiotics, and cancer drugs. Methods for searching novel drug candidates (drug development), development of computer models for prediction of various pharmacological properties, and structure-activity relationships are discussed.

Examination details

Grading scale: TH - (U,3,4,5) - (Fail, Three, Four, Five)
Assessment: Written assessment.

The examiner, in consultation with Disability Support Services, may deviate from the regular form of examination in order to provide a permanently disabled student with a form of examination equivalent to that of a student without a disability.

Admission

Required prior knowledge: KOOA15 General Chemistry, KOKA30 General, Inorganic and Organic Chemistry or KOKA05 Organic chemistry. KFKA05 Molecular Driving Forces 1: Thermodynamics or FAFA05 Physics - Waves, Thermodynamics and Atomic Physics. KBKA10 Biokemi, KBKA05 Technical Biology or EXTA70 Biology of the Cell.
The number of participants is limited to: No
The course overlaps following course/s: KOK085

Reading list

• Graham L P: An introduction to Medicinal Chemistry. Oxford University Press, 2013, ISBN: 978-0-19-969739-7. 5th edition.

Contact and other information

Course coordinator: Professor Ulf Nilsson, ulf.nilsson@chem.lu.se
Course homepage: http://www.chem.lu.se/education/Kemiteknik&Bioteknik/MedChem/MedChem.html