Course syllabus

Fysiologiska modeller och beräkningar
Physiological Models and Computations

FRTF01, 5 credits, G2 (First Cycle)

Valid for: 2016/17
Decided by: Education Board B
Date of Decision: 2016-03-29

General Information

Main field: Technology.
Compulsory for: BME3
Elective for: Pi4
Language of instruction: The course will be given in English

Aim

The aim of the course is to introduce important concepts, notions and methods in physiological modeling and computations including quantitative comparisons with physiological och medical measurements and phenomena. Explanation of physiological control using balance equations, dynamical systems, principles of feedback and adaptation.

Learning outcomes

Knowledge and understanding
For a passing grade the student must

know the organ systems of the human body and how they interact;
be aware of the fundamental principles for how different physiological phenomena can be measured and analyzed using insights from the body's metabolical, biomechanical, and bioelectrical properties.

Competences and skills
For a passing grade the student must

be able to decompose modeling problems into smaller subproblems;
be able to perform basic quantitative analysis of metabolical, biomechanical, and electro-physiological problems;
be able to make use of physiological modeling knowledge in simulations;
be able to apply physiological modeling in order to judge the relevance of different medical engineering solutions.

Judgement and approach
For a passing grade the student must

be able to interpret and discuss information from medical literature;
be able to communicate with healthcare professionals about physiological modeling and technical systems.

Physiological complexity: material and flow balances, energy balance, statics, stationarity, homeostasis, oscillations, dynamics, feedback, adaptation
Control in physiological systems: enzymes, hormones
Modeling: differential equations, dynamical systems, impulse response, disturbances, transfer functions, compartment models
Simulation; Malab, Simulink
Modeling and measurement data, system identification
Physiological models:
   - Enzyme dynamics
   - Radioactive trace analysis and turnover
   - Glucose and insuline dynamics
   - Biomechanical control: postural control, pupillary dynamics, gripping dynamics
   - Neural Modeling, Hodgkin-Huxley models
   - Pharmacokinetics: administration, absorption, distribution, elimination, metabolism, excretion
   - Blod flow control
   - Temperature control

Examination details

Grading scale: TH
Assessment: Written exam. Four hand-in exercises and one project.

Parts
Code: 0114. Name: Physiological Models and Computations.
Credits: 4. Grading scale: TH. Assessment: Passed exam
Code: 0214. Name: Hand-In 1.
Credits: 0. Grading scale: UG.
Code: 0314. Name: Hand-In 2.
Credits: 0. Grading scale: UG.
Code: 0414. Name: Hand-In 3.
Credits: 0. Grading scale: UG.
Code: 0514. Name: Hand-In 4.
Credits: 0. Grading scale: UG.
Code: 0614. Name: Project.
Credits: 1. Grading scale: UG. Assessment: Written report and oral presentation

Admission

Required prior knowledge: FMAA01 Calculus in One Variable, FMA420 Linear Algebra, TEK015 Human Physiology (or TEK171 Quantitative Human Physiology) and ETI265 Signal Processing in Multimedia.
The number of participants is limited to: No

Reading list

C Cobelli & E. Carson: Introduction to Modeling in Physiology and Medicine. Academic Press, 2008, ISBN: 978-0-12-160240-6.

Contact and other information

Course coordinator: Prof Rolf Johansson, Rolf.Johansson@control.lth.se
Director of studies: Prof Karl-Erik Årzén, karlerik@control.lth.se
Course homepage: http://www.control.lth.se/Education/EngineeringProgram.html

Fysiologiska modeller och beräkningar Physiological Models and Computations