Course syllabus
Fysiologiska modeller och beräkningar
Physiological Models and Computations
FRTF01, 5 credits, G2 (First Cycle)
Valid for: 2013/14
Decided by: Education Board B
Date of Decision: 2013-04-10
General Information
Main field: Technology.
Compulsory for: BME3
Elective for: Pi4
Language of instruction: The course will be given in Swedish
Aim
The aim of the course is to introduce important concepts,
notions and methods in physiological modeling and computations
including quantitative comparisons with physiological och medical
measurements and phenomena. Explanation of physiological control
using balance equations, dynamical systems, principles of feedback
and adaptation.
Learning outcomes
Knowledge and understanding
For a passing grade the student must
- know the organ systems of the human body and how they
interact;
- be aware of the fundamental principles for how different
physiological phenomena can be measured and analyzed using insights
from the body's metabolical, biomechanical, and bioelectrical
properties.
Competences and skills
For a passing grade the student must
- be able to decompose modeling problems into smaller
subproblems;
- be able to perform basic quantitative analysis of metabolical,
biomechanical, and electro-physiological problems;
- be able to make use of physiological modeling knowledge in
simulations;
- be able to apply physiological modeling in order to judge the
relevance of different medical engineering solutions.
Judgement and approach
For a passing grade the student must
- be able to interpret and discuss information from medical
literature;
- be able to communicate with healthcare professionals about
physiological modeling and technical systems.
Contents
- Physiological complexity: material and flow balances, energy
balance, statics, stationarity, homeostasis, oscillations,
dynamics, feedback, adaptation
- Control in physiological systems: enzymes, hormones
- Modeling: differential equations, dynamical systems, impulse
response, disturbances, transfer functions, compartment models
- Simulation; Malab, Simulink
- Modeling and measurement data, system identification
- Physiological models:
- Enzyme dynamics
- Radioactive trace analysis and turnover
- Glucose and insuline dynamics
- Biomechanical control: postural control, pupillary
dynamics, gripping dynamics
- Neural Modeling, Hodgkin-Huxley models
- Pharmacokinetics: administration, absorption,
distribution, elimination, metabolism, excretion
- Blod flow control
- Temperature control
Examination details
Grading scale: TH
Assessment: Written exam. Four hand-in exercises and one project.
Parts
Code: 0113. Name: Physiological Models and Computations.
Credits: 5. Grading scale: TH.
Code: 0213. Name: Hand-In 1.
Credits: 0. Grading scale: UG.
Code: 0313. Name: Hand-In 2.
Credits: 0. Grading scale: UG.
Code: 0413. Name: Hand-In 3.
Credits: 0. Grading scale: UG.
Code: 0513. Name: Hand-In 4.
Credits: 0. Grading scale: UG.
Code: 0613. Name: Project.
Credits: 0. Grading scale: UG.
Admission
Required prior knowledge: FMAA01 Calculus in One Variable, FMA420 Linear Algebra, TEK015 Human Physiology (or TEK171 Quantitative Human Physiology) and ETI265 Signal Processing in Multimedia.
The number of participants is limited to: No
Reading list
- C Cobelli & E. Carson: Introduction to Modeling in Physiology and Medicine. Academic Press, 2008, ISBN: 978-0-12-160240-6.
Contact and other information
Course coordinator: Prof Rolf Johansson, Rolf.Johansson@control.lth.se
Director of studies: Prof Karl-Erik Årzén, karlerik@control.lth.se
Course homepage: http://www.control.lth.se/Education/EngineeringProgram.html