Course syllabus

Läkemedelskemi
Medicinal Chemistry

KOK085, 7,5 credits, G2 (First Cycle)

Valid for: 2012/13
Decided by: Education Board 2
Date of Decision: 2012-04-04

General Information

Compulsory for: B4-l, K4-l
Elective for: N4-nbm
Language of instruction: The course will be given in English on demand

Aim

The aim of the course is to give basic knowledge in and broad understanding of medicinal chemistry and pharmacological principles from a molecular perspective.

Learning outcomes

Knowledge and understanding
For a passing grade the student must

• be able to describe the most common ways for drug development
• be able to describe common target molecules (proteins) for drug development
• be able to define basic pharmacodynamic and pharmacokinetic concepts
• be able to explain how computers are used in drug development

Competences and skills
For a passing grade the student must

• be able to discuss orally and in writing properties of drug molecules

Judgement and approach
For a passing grade the student must

• be able to analyse and judge a given molecular structure as potential drug candidat

Contents

The course discusses general pharmacological principles, drug development and presents various classes of drugs, their effects, their use, and chemical structures. Important parts of medicinal chemistry, such as drugs of the nerve system, hormone drugs, drugs affecting the heart, respiratory drugs, anaesthetics, sedative drugs, antivirals, antibiotics, and cancer drugs. Methods for searching novel drug candidates (drug development), development of computer models for prediction of various pharmacological properties, and structure-activity relationships are discussed.

Examination details

Grading scale: TH
Assessment: Written assessment.

Admission

Required prior knowledge: KOK012 Organic chemistry or a corresponding course.
The number of participants is limited to: No
The course might be cancelled: If the number of applicants is less than 5.

Reading list

• Graham L P: An introduction to Medicinal Chemistry. Oxford University Press, 4th edition, 2009. ISBN: 978-0-19-923447-9.

Contact and other information

Course coordinator: Professor Ulf Nilsson, ulf.nilsson@organic.lu.se
Course homepage: http://www.organic.lu.se/Education/Kemiteknik&Bioteknik/MedChem/MedChem.html