Syllabus academic year 2010/2011
(Created 2010-07-25.)
Credits: 7,5. Grading scale: TH. Cycle: A (Second Cycle). Main field: Technology. Language of instruction: The course will be given in English on demand. KOK090 overlaps following cours/es: KOK020 and KOK021. Optional for: B4l, K4l, K4m. Course coordinator: Univ.lecturer Kenneth Wärnmark,, Bioorganic Chemistry. Prerequisites: KOK012 Organic chemistry, basic course. Assessment: To pass the course you need to pass a written exam. Home page:

The aim of the course is to give advanced knowledge in synthetic organic chemistry and basic knowledge in physical organic chemistry.

Knowledge and understanding
For a passing grade the student must

Skills and abilities
For a passing grade the student must

The course primarily deals with organic reactions for the selective formation of carbon-carbon bonds. This includes enolate-chemistry, aromatic substitution, organometallic reactions, pericyclic reactions and radical chemistry. The course also includes oxidation and reduction reactions. The concepts of chemoselectivity, regioselectivity and stereoselectivity are emphasized. Retrosynthetic analysis of target molecules is brought up on a basic level. The mechanisms of important reactions are examined to understand the outcome of these reactions with regard to selectivity. The most important name reactions are taught. A comprehensive part of the course deals with tools to elucidate reaction mechanisms, f. ex. linear free energy relationships and primary kinetic isotope effect.

An important aspect of the course is to be able to draw clear drawings of organic structures and to be able to present organic reactions and mechanisms orally and in writing. The role of organic chemistry in drug development and synthesis and the synthesis of complex organic molecules will be emphasized.


Clayden, J, Greeves, N, Warren, S, Wothers, P: Organic Chemistry. Oxford University Press 2001. ISBN 0-19-850346-6.