Syllabus academic year 2009/2010
(Created 2009-08-11.)
STATISTICAL GENETICSFMSN01

Higher education credits: 7,5. Grading scale: TH. Level: A (Second level). Language of instruction: The course will be given in English on demand. FMSN01 overlap following cours/es: FMS160, MAS235, MASM16, FMS160, MAS235, MASM16, MASM20, FMS160, MAS235, MASM16 och MASM20. Optional for: Pi4, Pi4bm. Course coordinator: Anna Lindgren, Director of studies, anna@maths.lth.se, Matematisk statistik. Recommended prerequisits: A basic course in mathematical statistics and an additional course in stochastic processes. The course might be cancelled if the numer of applicants is less than 16. Assessment: Home exam, compulsory computer exercises, and oral project presentation. The course grade is based 90% on the home exam and 10% on the project presentation. Parts: 2. Further information: May not be included together with FMS160. Home page: http://www.maths.lth.se/matstat/kurser/fmsn01/.

Aim
In a theoretical as well as practical way teach the student the most fundamental statistical methods in genetic epidemiology.

Knowledge and understanding
For a passing grade the student must

Skills and abilities
For a passing grade the student must

Contents
The course covers methods for using statistical methods in gene mapping for human hereditary diseases, i.e. localising corresponding chromosome positions in the human genome.

Initially, an introduction to statistical genetics is presented, including genetical definitions. Secondly, theory and methodology within the fields of parametric- and nonparametric linkage analysis and association analysis are discussed.

Literature
Ziegler, A., K├Ânig, I.: A Statistical Approach to Genetic Epidemiology. Wiley-VCH 2006. ISBN 978-3-527-31252-8

Parts

Code: 0108. Name: Written Examination.
Higher education credits: 6. Grading scale: TH. Assessment: Written take home examination.

Code: 0208. Name: Project.
Higher education credits: 1,5. Grading scale: UG. Assessment: Written and oral project report.