Syllabus academic year 2008/2009
(Created 2008-07-17.)
MOLECULAR MICROBIOLOGYEXTN55

Higher education credits: 15. Grading scale: UV. Level: A (Second level). Language of instruction: The course might be given in English. EXTN55 overlap following cours/es: TEK297. Optional for: N4. Course coordinator: Claes von Wachenfeldt, Claes.von_Wachenfeldt@cob.lu.se, Inst f cell- och organismbiologi. Prerequisites: TEK285 Chemistry – from General Chemistry to the Molecules of Life, TEK295 Biology of the Cell and TEK015 Human Physiologyand TEK012 Genetics and Microbiology. The number of participants is limited to 5 Selection criteria: Credits remaining for the degree. Assessment: Teaching consists of lectures, practicals and seminars. Practicals and seminars, and the course elements associated with these are compulsory. Examination takes the form of written tests at the end of the course. Students who fail the ordinary tests will have an opportunity to take another test in close proximity to the ordinary test. To be awarded a Pass on the whole course the students shall have passed the tests, have acceptable practical reports and to have participated in all compulsory course elements. The final grade for the course is determined by the aggregated results of the different parts of the examination. Home page: http://www.cob.lu.se.

Aim
The aim of the course is to provide knowledge for advanced studies, work and research especially within chemical-biological-biochemical areas.

Knowledge and understanding
For a passing grade the student must

Skills and abilities
For a passing grade the student must

Contents
Bacteria make up the foundation of the biosphere and sustain all life on earth. This course provides insights into how genes are organised and regulated in bacteria and in their viruses. The course comprises molecular biology of genes, proteins, multicomponent protein complexes, and other biomolecules that provide structure and perform the organism’s functions. The use of genetic engineering and modern techniques such as transcriptomics, proteomics and sequence analysis are included in the course. The experimental part focus on the most studied bacteria, Bacillus subtilis, Escherichia coli and Streptomyces coelicolor. The course content include: structure, organization and replication of bacterial and viral genomes; Gene expression; Bacterial genetic analysis; DNA repair and mutagenesis; Regulation of gene expression; Global gene regulation; Bacterial developmental processes; Genetic engineering.

Literature
According to a list established by the department, available at least five weeks before the start of the course, see the web-page for Undergraduate Studies in Biology.