Syllabus 2008/2009 EXTN50

Syllabus academic year 2008/2009
(Created 2008-07-17.)

TOXICOLOGY

EXTN50

Higher education credits: 15. Grading scale: UV. Level: A (Second level). Language of instruction: The course might be given in English. EXTN50 overlap following cours/es: TEK299. Optional for: N4, N4nbm. Course coordinator: Stina Oredsson, Stina.Oredsson@cob.lu.se, Inst f cell- och organismbiologi. Prerequisites: TEK285 Chemistry from General Chemistry to the Molecules of Life, TEK295 Biology of the Cell, TEK015 Human Physiology, TEK017 Human Physiology. The number of participants is limited to 2 Selection criteria: Credits remaining for the degree. Assessment: Teaching consists of lectures, practicals and seminars. Practicals are accounted for in writing, which are graded. A literature study is accounted for in writing and by oral presentation. Practicals and seminars, and the course elements associated with these are compulsory. Examination takes the form of written tests at the end of the course. Students who fail the ordinary tests will have an opportunity to take another test in close proximity to the ordinary test. To be awarded a Pass on the whole course the students shall have passed the tests, have acceptable practical reports and to have participated in all compulsory course elements. The final grade for the course is determined by the aggregated results of the different parts of the examination. Home page: http://www.cob.lu.se.

Aim
The aim of the course is to provide knowledge for advanced studies, work and research especially within chemical-biological-biochemical areas.

Knowledge and understanding
For a passing grade the student must

have acquired knowledge about the basic concepts of toxicology
have acquired knowledge about toxicokinetics and biotransformation/bioactivation
have acquired knowledge of how toxic compounds act on the molecular, cellular, organ and organism levels.

Skills and abilities
For a passing grade the student must

have acquired knowledge about toxicological methods mainly in vitro techniques
have acquired training in writing and oral communication
have acquired basis for further studies and trade

Contents
General toxicological knowledge. Uptake, distribution and excretion of xenobiotic compounds (toxicokinetics). Mechanism of action of xenobiotics on molecular, cellular, tissue, organ and organism level (toxicodynamics). Turnover of xenobiotics (biotransformation/bioactivation). Immuntoxicology. Neurotoxicology. Genotoxicology. Reproductive toxicology. Legislation. Methods to study toxicology with emphasis on in vitro toxicology.

Literature
According to a list established by the department, available at least five weeks before the start of the course, see the web-page for Undergraduate Studies in Biology.