Syllabus academic year 2007/2008
STATISTICAL GENETICSFMS160

Higher education credits: 4,5. Grading scale: TH. Level: A (Second level). Language of instruction: The course will be given in English on demand. FMS160 overlap following cours/es: MAS235, FMSN01 och MAS235. Optional for: Pi4bm. Course coordinator: Anna Lindgren, Director of studies, anna@maths.lth.se, Matematisk statistik. Recommended prerequisits: A basic course in mathematical statistics and an additional course in stochastic processes. Assessment: Home exam, compulsory computer exercises, and oral project presentation. The course grade is based 90% on the home exam and 10% on the project presentation. Further information: The course is also given at the faculty of science with the code MAS235. The course may not be included together with BNF073. Home page: http://www.maths.lth.se/matstat/kurser/fms160mas235/.

Aim
In a theoretical as well as practical way teach the student the most fundamental statistical methods in genetic epidemiology.

Knowledge and understanding
For a passing grade the student must

Skills and abilities
For a passing grade the student must

Contents
The course covers methods for using statistical methods in gene mapping for human hereditary diseases, i.e. localising corresponding chromosome positions in the human genome.

Initially, an introduction to statistical genetics is presented, including genetical definitions. Secondly, theory and methodology within the fields of parametric- and nonparametric linkage analysis and association analysis are discussed.

Literature
Lecture notes and additional material.